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Article

Microfluidic bead-based enzymatic primer extension for single-nucleotide discrimination using quantum dots as labels.

Analytical biochemistry - 1 Jul 2012

Zhang He, Fu Xin, Liu Lian, Zhu Zhenjun, Yang Ke

Abstract excerpt

This study reports the development of an on-chip enzyme-mediated primer extension process based on a microfluidic device with microbeads array for single-nucleotide discrimination using quantum dots as labels. The functionalized microbeads were independently introduced into the arrayed chambers using the loading chip slab. A single channel was used to generate weir structures to confine the microbeads and make...

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PMID: 22487314
DOI: 10.1016/j.ab.2012.03.030

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