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Multiplexed single nucleotide polymorphism genotyping by oligonucleotide ligation and flow cytometry.

Cytometry - 1 Feb 2000

Iannone M A, Taylor J D, Chen J, Li M S, Rivers P, Slentz-Kesler K A, Weiner M P

Abstract excerpt

BACKGROUND: We have developed a rapid, high throughput method for single nucleotide polymorphism (SNP) genotyping that employs an oligonucleotide ligation assay (OLA) and flow cytometric analysis of fluorescent microspheres. METHODS: A fluoresceinated oligonucleotide reporter sequence is added to a "capture" probe by OLA. Capture probes are designed to hybridize both to genomic "targets" amplified by polymerase...

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PMID: 10679731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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