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Article

Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma.

International journal of cancer - 1 May 2001

Van Gele M, Leonard J H, Van Roy N, Cook A L, De Paepe A, Speleman F

Abstract excerpt

Merkel cell carcinoma (MCC) is a rare, highly metastatic skin tumor of neuroectodermal origin. The disease shares clinical and histopathological features with small cell lung carcinoma (SCLC). The genetic mechanisms underlying the development and tumor progression of MCC are poorly understood. We...

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Topics

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Share to Carcinoma, Merkel Cell
Share to Chromosomes, Human, Pair 10
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to Skin Neoplasms

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 11291079
DOI: 10.1002/ijc.1209

Genes

MCC
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11291079-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma.PMID 11291079Read ↗

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