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Article

Epigenetic PTEN silencing in malignant melanomas without PTEN mutation.

The American journal of pathology - 1 Oct 2000

Zhou X P, Gimm O, Hampel H, Niemann T, Walker M J, Eng C

Abstract excerpt

A tumor suppressor gene at 10q 23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers. Germline mutations in PTEN cause Cowden syndrome (CS), which is characterized by multiple hamartomas and a high risk of breast and thyroid cancers. Frequent loss of heterozygosity at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11021816
DOI: 10.1016/S0002-9440(10)64627-5
PMCID: PMC1850161

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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