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Article

Lack of somatic mutation in the PTEN gene in squamous cell carcinomas of human skin.

Journal of dermatological science - 1 Apr 1999

Kubo Y, Urano Y, Hida Y, Arase S

Abstract excerpt

The tumor suppressor gene PTEN is deleted and/or mutated in a variety of tumors and the susceptibility gene for Cowden disease. Loss of heterozygosity of chromosome 10q23, where PTEN resides, in squamous cell carcinomas (SCCs) of human skin and the association of SCC with Cowden disease were repo...

Read the complete abstract on PubMed

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Share to Carcinoma, Squamous Cell
Share to DNA, Neoplasm
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoric Monoester Hydrolases

Share to Polymorphism, Single-Stranded Conformational

Share to PTEN Phosphohydrolase

Share to Skin Neoplasms

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Source

Identifiers

PMID: 10215192
DOI: 10.1016/s0923-1811(98)00058-9

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10215192-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of somatic mutation in the PTEN gene in squamous cell carcinomas of human skin.PMID 10215192Read ↗

Epigenetic PTEN silencing in malignant melanomas without PTEN mutation.Semantic proximity Read ↗

Polymorphisms in PTEN in breast cancer families.Semantic proximity Read ↗

Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma.Semantic proximity Read ↗

Evaluation of germline PTEN mutations in endometrial cancer patients.Semantic proximity Read ↗

Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors.Semantic proximity Read ↗

Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations.Semantic proximity Read ↗

Homozygous deletion of the PTEN tumor-suppressor gene is not a feature in oral squamous cell carcinoma.Semantic proximity Read ↗

Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus.Semantic proximity Read ↗

Analysis of PTEN gene mutations in a Turkish patient with Cowden syndrome.Semantic proximity Read ↗

Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden disease.Semantic proximity Read ↗

Expression of the PTEN tumour suppressor protein during human developmentSemantic proximity Read ↗

Somatic mutation of PTEN in vulvar cancer.Semantic proximity Read ↗

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