Article
Mutation analysis of left-right axis determining genes in NOD and ICR, strains susceptible to maternal diabetes.
Teratology - 1 Mar 2001
Maeyama K, Kosaki R, Yoshihashi H, Casey B, Kosaki K
Abstract excerpt
BACKGROUND: Genetic background of the fetus contributes to the pathogenesis of congenital malformation after teratogen exposure. Such contribution is illustrated in left-right axis malformations observed in the F1 offspring of nonobese diabetic (NOD) mouse dams and sires from different strains. When sires of the NOD, ICR, or C57BL/6J were mated with NOD dams, incidence varied depending on the fetal genotype, with...
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