Article
Diabetic embryopathy in C57BL/6J mice. Altered fetal sex ratio and impact of the splotch allele.
Diabetes - 1 May 2001
Machado A F, Zimmerman E F, Hovland D N, Weiss R, Collins M D
Abstract excerpt
Maternal diabetes (types 1 and 2) induces a broad array of congenital malformations, including neural tube defects (NTDs), in humans. One of the difficulties associated with studying diabetic embryopathy is the rarity of individual malformations. In an attempt to develop a sensitive animal model for maternal diabetes-induced NTDs, the present study uses chemically induced diabetes in an inbred mouse model with or...
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