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Article

Linkage study of embryopathy-polygenic inheritance of diabetes-induced skeletal malformations in the rat.

Reproductive toxicology (Elmsford, N.Y.) - 1 Jun 2012

Nordquist Niklas, Luthman Holger, Pettersson Ulf, Eriksson Ulf J

Abstract excerpt

We developed an inbred rat model of diabetic embryopathy, in which the offspring displays skeletal malformations (agnathia or micrognathia) when the mother is diabetic, and no malformations when she is not diabetic. Our aim was to find genes controlling the embryonic maldevelopment in a diabetic environment. We contrasted the fetal outcome in inbred Sprague-Dawley L rats (20% skeletal malformations in diabetic...

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PMID: 22227068
DOI: 10.1016/j.reprotox.2011.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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