Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.

Nucleic acids research - 1 Dec 2013

Wolf Louise, Harrison Wilbur, Huang Jie, Xie Qing, Xiao Ningna, Sun Jian, Kong Lingkun, Lachke Salil A, Kuracha Murali R, Govindarajan Venkatesh, Brindle Paul K, Ashery-Padan Ruth, Beebe David C, Overbeek Paul A, Cvekl Ales

Abstract excerpt

Lens induction is a classical embryologic model to study cell fate determination. It has been proposed earlier that specific changes in core histone modifications accompany the process of cell fate specification and determination. The lysine acetyltransferases CBP and p300 function as principal enzymes that modify core histones to facilitate specific gene expression. Herein, we performed conditional inactivation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to CREB-Binding Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to E1A-Associated p300 Protein

Share to Embryonic Induction

Share to Histones

Share to Lens, Crystalline

Share to Protein Processing, Post-Translational

Share to S Phase

Source

Open in PubMed Open full text

Identifiers

PMID: 24038357
DOI: 10.1093/nar/gkt824
PMCID: PMC3905850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300.PMID 24038357Read ↗

Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation.Semantic proximity Read ↗

Differential contribution of p300 and CBP to regulatory element acetylation in mESCsSemantic proximity Read ↗

Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.Semantic proximity Read ↗

CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryosSemantic proximity Read ↗

Is histone acetylation the most important physiological function for CBP and p300?Semantic proximity Read ↗

The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosisSemantic proximity Read ↗

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing ForebrainSemantic proximity Read ↗

Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.Semantic proximity Read ↗

Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells.Semantic proximity Read ↗

Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafishSemantic proximity Read ↗

A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye.Semantic proximity Read ↗

Dysregulation of the p300/CBP histone acetyltransferases in human cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.