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Article

Bone morphogenetic proteins: from structure to clinical use

1 Oct 2005

Abstract excerpt

Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor ss superfamily. Family members are expressed during limb development, endochondral ossification, early fracture, and cartilage repair. The activity of BMPs was first identified in the 1960s but the proteins responsible for bone induction were unknown until the purification and cloning of human BMPs...

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PMID: 16172739
DOI: 10.1590/s0100-879x2005001000003

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