Article
Homocysteine and the MTHFR 677C-->T allele in premature coronary artery disease. Case control and family studies.
European journal of clinical investigation - 1 Jan 2001
Pintó X, Vilaseca M A, Garcia-Giralt N, Ferrer I, Palá M, Meco J F, Mainou C, Ordovás J M, Grinberg D, Balcells S
Abstract excerpt
BACKGROUND: The aim of this work was to evaluate the role of homocysteine, and the MTHFR 677C-->T allele as risk factors for premature coronary artery disease and to analyse the inheritance of this metabolic disorder. MATERIAL AND METHODS: Case-control and family studies were performed in a sample of 76 male patients (age < 55), 95 age-matched controls and 89 patients' offspring. Plasma total homocysteine...
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