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Conditional <i>Dystrophin</i> ablation in the skeletal muscle and brain causes profound effects on muscle function, neurobehavior, and extracellular matrix pathways

2025-02-01

Abstract excerpt

Duchenne muscular dystrophy (DMD) patients suffer from skeletal and cardiopulmonary weakness, and interestingly up to one third are diagnosed on the autism spectrum. Dystrophin is an essential protein for regulating the transmission of intracellular force to the extracellular matrix within the skeletal muscle, but also plays key roles in neurobehavior and cognitive function. The mouse dystrophin gene (also abbrevi...

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Literature Corpus work
970ee539-4a33-533a-9baa-e73f07f81c0e
DOI
10.1101/2025.01.30.635777
Open publication

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Conditional <i>Dystrophin</i> ablation in the skeletal muscle and brain causes profound effects on muscle function, neurobehavior, and extracellular matrix pathwaysDOI 10.1101/2025.01.30.635777
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