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Article

Chromosomal stability and the DNA double-stranded break connection.

Nature reviews. Genetics - 1 Mar 2001

van Gent D C, Hoeijmakers J H, Kanaar R

Abstract excerpt

Genome stability is of primary importance for the survival and proper functioning of all organisms. Double-stranded breaks in DNA are important threats to genome integrity because they can result in chromosomal aberrations that can affect, simultaneously, many genes, and lead to cell malfunctioning and cell death. These detrimental consequences are counteracted by two mechanistically distinct pathways of...

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PMID: 11256071
DOI: 10.1038/35056049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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