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More powerful dysregulation of Helicobacter pylori East Asian-type CagA on intracellular signalings

11 Nov 2024

Abstract excerpt

Chronic infection by Helicobacter pylori strains expressing cytotoxin-associated gene A (CagA) are the strongest risk factor for gastric cancer. CagA can be classified into East Asian-type and Western-type (CagA E and CagA W ), with CagA E being more closely associated with gastric cancer. This study aimed to investigate the impact of CagA E on intracellular signaling pathways to explain its high oncogenicity....

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PMID: 39528935
DOI: 10.1186/s12866-024-03619-4

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