Article
Assessment of parent-of-origin effects in linkage analysis of quantitative traits.
American journal of human genetics - 1 Apr 2001
Hanson R L, Kobes S, Lindsay R S, Knowler W C
Abstract excerpt
Methods are presented for incorporation of parent-of-origin effects into linkage analysis of quantitative traits. The estimated proportion of marker alleles shared identical by descent is first partitioned into a component derived from the mother and a component derived from the father. These parent-specific estimates of allele sharing are used in variance-components or Haseman-Elston methods of linkage analysis...
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