Linkage analysis of affected sib pairs allowing for parent-of-origin effects.

doi:10.1046/j.1529-8817.2004.00139.x

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Article

Linkage analysis of affected sib pairs allowing for parent-of-origin effects.

Annals of human genetics - 1 Jan 2005

Wu Chih-Chieh, Shete Sanjay, Amos Christopher I

Abstract excerpt

Parent-of-origin effects, also known as genomic imprinting, exist for many mammalian genes. For imprinted genes the expression of an allele depends upon the sex of the transmitting parent. Here we have developed a method based on alleles that are shared identical by descent by affected sib pairs, that allows for parent-of-origin effects. Our method allows for sex-specific recombination rates, an important...

Topics

Alleles
Chromosome Mapping
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genomic Imprinting
Humans
Lod Score
Male
Models, Genetic
Parents
Quantitative Trait, Heritable
Siblings

Source

Open in PubMed

Identifiers

PMID: 15638832
DOI: 10.1046/j.1529-8817.2004.00139.x

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