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Article

Miscoding and misincorporation of 8-oxo-guanine during leading and lagging strand synthesis in Escherichia coli.

Molecular & general genetics : MGG - 1 Feb 2001

Watanabe T, van Geldorp G, Najrana T, Yamamura E, Nunoshiba T, Yamamoto K

Abstract excerpt

We examined whether strand identity with respect to DNA replication influences strand bias for 8-oxo-7,8-dihydroguanine (8-oxoG) mutagenesis. The specificity of 8-oxoG mutagenesis was determined in a mutM mutY or a mutT strain carrying the supF gene on one of two vectors that differed only in the orientation of supF with respect to a unique origin of replication. Most of the supF mutations in the mutM mutY strain...

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PMID: 11254131
DOI: 10.1007/s004380000373

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