Article
SOS mutator activity: unequal mutagenesis on leading and lagging strands.
Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 2000
Maliszewska-Tkaczyk M, Jonczyk P, Bialoskorska M, Schaaper R M, Fijalkowska I J
Abstract excerpt
A major pathway of mutagenesis in Escherichia coli is mediated by the inducible SOS response. Current models of SOS mutagenesis invoke the interaction of RecA and UmuD'(2)C proteins with a stalled DNA replication complex at sites of DNA lesions or poorly extendable terminal mismatches, resulting in an (error-prone) continuation of DNA synthesis. The precise mechanisms of SOS-mediated lesion bypass or mismatch...
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