Article
Constitutively active mutants of 5-HT4 receptors are they in unique active states?
EMBO reports - 1 Jan 2001
Claeysen S, Sebben M, Bécamel C, Parmentier M L, Dumuis A, Bockaert J
Abstract excerpt
Somatic mutations leading to constitutively active G-protein coupled receptors (GPCRs) are responsible for certain human diseases. A consistent structural description of the molecular change underlying the conversion of GPCRs from an inactive R state to an active R* state is lacking. Here, we show that a series of constitutively active 5-HT4 receptors (mutated or truncated in the C-terminal and the third...
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