Article
Impaired induction of heat shock protein implicated in decreased thermotolerance in a temperature-sensitive multinucleated cell line.
Pflugers Archiv : European journal of physiology - 1 Dec 1998
Cao Y, Matsumoto T, Motomura K, Ohtsuru A, Yamashita S, Kosaka M
Abstract excerpt
Cells of a temperature-sensitive mutant line (tsFT101) derived from a mouse mammary carcinoma cell line (FM3A) become multinucleated at a non-permissive temperature of 39 degrees C because of disturbed cytokinesis. To explore how this relates to thermotolerance, we examined the proliferative activity of, and heat shock protein (HSP) expression in, FM3A and tsFT101 cells cultured at 37 degrees C and 39 degrees C...
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