Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens.

doi:10.1084/jem.194.3.285

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Article

Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens.

The Journal of experimental medicine - 6 Aug 2001

Beck-Engeser G B, Monach P A, Mumberg D, Yang F, Wanderling S, Schreiber K, Espinosa R, Le Beau M M, Meredith S C, Schreiber H

Abstract excerpt

Antigens that are tumor specific yet retained by tumor cells despite tumor progression offer stable and specific targets for immunologic and possibly other therapeutic interventions. Therefore, we have studied two CD4(+) T cell-recognized tumor-specific antigens that were retained during evolution of two ultraviolet-light-induced murine cancers to more aggressive growth. The antigens are ribosomal proteins...

Topics

Alleles
Amino Acid Sequence
Animals
Antigens, Neoplasm
Base Sequence
CD4-Positive T-Lymphocytes
DNA Primers
DNA, Neoplasm
In Situ Hybridization, Fluorescence
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Neoplasms, Radiation-Induced

Point Mutation

RNA, Messenger

RNA, Neoplasm

Ribosomal Proteins

Tumor Cells, Cultured

Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 11489948
DOI: 10.1084/jem.194.3.285
PMCID: PMC2193475

Provenance

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