Article
Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 2002
Symons R C Andrew, Daly Mark J, Fridlyand Jane, Speed Terence P, Cook Wendy D, Gerondakis Steven, Harris Alan W, Foote Simon J
Abstract excerpt
There is a great difference in susceptibility to v-abl transgene-induced plasmacytoma between the BALB/cAn and the relatively resistant C57BL/6J mouse strains. We have used the Mapmaker/SURVIVOR algorithm to analyze genome-wide scans on over 800 transgenic F2 hybrid mice, and have mapped at least six loci on chromosomes 2, 4, 11, 17, and 18 that modify tumor-related morbidity. As in human multiple myeloma, males...
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