Article
Screening mouse mutations for resistance to cancer metastasis.
Immunogenetics - 1 Jan 1992
Egorov O S, Liu Y, Sargent E E, Drizlikh G I, Egorov I K
Abstract excerpt
To search for host genes for resistance/susceptibility to cancer metastasis, mutation analysis was employed. Ten putative mutants of resistance to lymphoma EL4 and four putative mutants of resistance to sarcoma MCA/77-23 of C57BL/6J (B6) mice were produced. These mutants were designated S (for "survivor") mutants; they do not reject parental strain B6 skin grafts. S-mutants resist moderate tumor cell doses: TD50...
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