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Article

Radiation inducible MafB gene is required for thymic regeneration.

Scientific reports - 17 May 2021

Hashimoto Daiki, Colet Jose Gabriel R, Murashima Aki, Fujimoto Kota, Ueda Yuko, Suzuki Kentaro, Hyuga Taiju, Hemmi Hiroaki, Kaisho Tsuneyasu, Takahashi Satoru, Takahama Yousuke, Yamada Gen

Abstract excerpt

The thymus facilitates mature T cell production by providing a suitable stromal microenvironment. This microenvironment is impaired by radiation and aging which lead to immune system disturbances known as thymic involution. Young adult thymus shows thymic recovery after such involution. Although various genes have been reported for thymocytes and thymic epithelial cells in such processes, the roles of stromal...

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Identifiers

PMID: 34001954
DOI: 10.1038/s41598-021-89836-7
PMCID: PMC8129107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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