Article
Hidden variables: unstable Abeta chain genes encoding antigen recognition structures in tumor survivors.
Molecular immunology - 1 Dec 2000
Liu Y, McMinimy D L, Savinov A Y, Johnson K A, Kremlev S G, Chapoval A I, Egorov I K
Abstract excerpt
Novel single exon genes Abeta4-7 comprising the Abeta6 gene family have been cloned from mouse mutants surviving transplantable metastatic tumors. Their protein coding sequences are similar to H2-Ab cDNA which encodes antigen-binding molecules of antigen presenting cells (APC); their promoters and/or signal sequences are unrelated to Ab sequences but found in other eukaryotic genes. Abeta4(b) protein was...
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