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Article

An RNA Ligase Essential for RNA Editing and Survival of the Bloodstream Form of <i>Trypanosoma brucei</i>

16 Mar 2001

Abstract excerpt

RNA editing in trypanosomes occurs by a series of enzymatic steps that are catalyzed by a macromolecular complex. The TbMP52 protein is shown to be a component of this complex, to have RNA ligase activity, and to be one of two adenylatable proteins in the complex. Regulated repression of TbMP52 blocks editing, which shows that it is a functional component of the editing complex. This repression is lethal in...

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PMID: 11251122
DOI: 10.1126/science.1058955

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An RNA Ligase Essential for RNA Editing and Survival of the Bloodstream Form of <i>Trypanosoma brucei</i>PMID 11251122Read ↗

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