The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1.

doi:10.1113/jphysiol.1996.sp021411

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Article

The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1.

The Journal of physiology - 15 Jun 1996

Abrams C J, Davies N W, Shelton P A, Stanfield P R

Abstract excerpt

1. The effects of Rb+ and Cs+ as blocking ions were investigated on wild-type and mutant forms of the inward rectifier K+ channel, IRK1 (Kir2.1). 2. In wild-type channels, Rb+ blockage was voltage dependent, increasing and then falling with increasing hyperpolarization. 3. Rb+ blockage was abolis...

Topics

Animals
Aspartic Acid
Cesium
DNA
Electrophysiology
Ion Channel Gating
Membrane Potentials
Mice
Mutation
Patch-Clamp Techniques
Permeability
Potassium Channels
Rubidium

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