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Article

The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1.

The Journal of physiology - 15 Jun 1996

Abrams C J, Davies N W, Shelton P A, Stanfield P R

Abstract excerpt

1. The effects of Rb+ and Cs+ as blocking ions were investigated on wild-type and mutant forms of the inward rectifier K+ channel, IRK1 (Kir2.1). 2. In wild-type channels, Rb+ blockage was voltage dependent, increasing and then falling with increasing hyperpolarization. 3. Rb+ blockage was abolished by replacing Asp172 in the M2 domain of the pore-forming subunit by Asn, but was re-established by a change to Gln,...

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Identifiers

PMID: 8799888
DOI: 10.1113/jphysiol.1996.sp021411
PMCID: PMC1159014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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