Novel alleles at the lymphotoxin alpha (LTalpha) locus mark extended HLA haplotypes in native Africans.

doi:10.1016/s0198-8859(00)00252-4

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Article

Novel alleles at the lymphotoxin alpha (LTalpha) locus mark extended HLA haplotypes in native Africans.

Human immunology - 1 Mar 2001

Tang J, Myracle A D, Allen S, Karita E, Musonda R, Fultz P N, Kaslow R A

Abstract excerpt

Genetic variations at the closely related tumor necrosis factor alpha (TNFalpha or TNF) and lymphotoxin alpha (LTalpha, formerly TNFbeta) loci have been well documented in various human populations, and several haplotypes spanning the MHC class I and class II loci are known to carry specific TNF alleles. Genotyping of the TNFc microsatellite within the first intron of LTalpha in 285 Rwandans and 319 Zambians...

Topics

Africa
Alleles
Animals
Black People
CD4 Antigens
Female
Genetic Variation
Genotype
HIV Seronegativity
HIV Seropositivity
Haplotypes
Humans
Lymphotoxin-alpha
Pan troglodytes
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 11250044
DOI: 10.1016/s0198-8859(00)00252-4

Genes

TAP1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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