Article
Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk.
Human genetics - 1 May 2007
Gaudet Mia M, Egan Kathleen M, Lissowska Jolanta, Newcomb Polly A, Brinton Louise A, Titus-Ernstoff Linda, Yeager Meredith, Chanock Stephen, Welch Robert, Peplonska Beata, Trentham-Dietz Amy, Garcia-Closas Montserrat
Abstract excerpt
Tumor necrosis factor (TNF) is critical to regulation of inflammation. Genetic variation in the promoter region of TNF has been associated with expression differences, and a range of auto-immune, infectious, and oncologic diseases. We analyzed eight common single nucleotide polymorphisms (SNPs) (rs746868, rs909253, rs1799964, rs1800630, rs1800750, , , and ) to capture most of the genetic...