Article
DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1991
Nedospasov S A, Udalova I A, Kuprash D V, Turetskaya R L
Abstract excerpt
TNF-alpha and lymphotoxin (LT, TNF-beta) genes are tandemly arranged and map within the MHC centromeric to HLA-B and telomeric to the class III genes. Both cytokines encoded by these genes are potent immunomodulators. On the other hand, some MHC-linked autoimmune diseases are characterized by abnormal levels of their expression or inducibility. A search for the putative disease-associated TNF/LT alleles depends...
Topics
- Alleles
- Base Sequence
- Blotting, Southern
- Chromosome Mapping
- DNA, Satellite
- Humans
- Lymphotoxin-alpha
- Molecular Sequence Data
- Oligonucleotide Probes
- Pedigree