Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6.

doi:10.1186/s12862-019-1516-y

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Article

Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6.

BMC evolutionary biology - 2 Dec 2019

Campbell Michael C, Ashong Bryan, Teng Shaolei, Harvey Jayla, Cross Christopher N

Abstract excerpt

BACKGROUND: Lymphotoxin-α (LTα), located in the Major Histocompatibility Complex (MHC) class III region on chromosome 6, encodes a cytotoxic protein that mediates a variety of antiviral responses among other biological functions. Furthermore, several genotypes at this gene have been implicated in the onset of a number of complex diseases, including myocardial infarction, autoimmunity, and various types of cancer....

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Identifiers

PMID: 31791241
DOI: 10.1186/s12862-019-1516-y
PMCID: PMC6889576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.