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Article

Novel polymorphisms and the definition of promoter 'alleles' of the tumor necrosis factor and lymphotoxin alpha loci: inclusion in HLA haplotypes.

Genes and immunity - 1 Dec 2003

Posch P E, Cruz I, Bradshaw D, Medhekar B A

Abstract excerpt

Tumor necrosis factor (TNF) and lymphotoxin alpha (LTA) influence a variety of cellular responses and play a complex role in the immune response. Several single nucleotide polymorphisms (SNPs) have been reported in these major histocompatibility complex (MHC)-linked loci; however, a comprehensive examination of polymorphisms in the promoter regions of TNF and LTA has not been carried out and was undertaken here....

Topics

Alleles
Base Sequence
Chromosome Mapping
Cluster Analysis
Genotype
HLA Antigens
Humans
Lymphotoxin-alpha
Molecular Sequence Data
Phylogeny
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Sequence Analysis, DNA

Sequence Homology

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 14647194
DOI: 10.1038/sj.gene.6364023

Genes

LTA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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