Article
E-cadherin gene mutations in human intrahepatic cholangiocarcinoma.
The Journal of pathology - 1 Mar 2001
Endo K, Ashida K, Miyake N, Terada T
Abstract excerpt
Deletions or mutations of the E-cadherin gene may result in reduced cell adhesiveness. In particular, conservative point mutations within the N-terminal calcium-binding pocket (including exons 7, 8, and 9) are frequently detected in several cancers and are enough to abolish cell-cell adhesion. Th...
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