Article
Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations.
Mutation research - 1 Mar 2001
Mott J L, Zhang D, Stevens M, Chang S, Denniger G, Zassenhaus H P
Abstract excerpt
With age, mitochondrial DNA mutations and oxidative stress increase, leading to the hypothesis that the production of reactive oxygen species causes the pathogenic effects of mitochondrial DNA mutations. We tested this hypothesis using transgenic mice that develop cardiomyopathy due to the accumulation of mitochondrial DNA mutations specifically in the heart. Surprisingly, the mechanism of pathogenesis does not...
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