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Article

Mitochondrial DNA mutations activate programmed cell survival in the mouse heart.

American journal of physiology. Heart and circulatory physiology - 1 May 2005

Zhang Dekui, Mott Justin L, Chang Shin-Wen, Stevens Melissa, Mikolajczak Peter, Zassenhaus H Peter

Abstract excerpt

Increased frequencies of mitochondrial DNA (mtDNA) mutations characterize the aging heart and are also found in idiopathic dilated cardiomyopathy and end-stage heart failure. The pathogenic potential of such mutations is unclear. Transgenic mice showing accelerated accumulation of mtDNA mutations...

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Identifiers

PMID: 15840907
DOI: 10.1152/ajpheart.00670.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15840907-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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