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Article

Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1.

Frontiers in immunology - 1 Jan 2021

Lin Yun Hsiao, Liang Yue, Wang HanChen, Tung Lin Tze, Förster Michael, Subramani Poorani Ganesh, Di Noia Javier M, Clare Simon, Langlais David, Nijnik Anastasia

Abstract excerpt

BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, via deubiquitination of histone H2AK119ub and other substrates. BAP1 is an important tumor suppressor in human, expressed and functional across many cell-types and tissues, including those of the immune system. B lymphocytes are the mediators of humoral immune response,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33912157
DOI: 10.3389/fimmu.2021.626418
PMCID: PMC8072452

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