Article
Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.
Journal of leukocyte biology - 1 Jan 2011
Martínez-Florensa Mario, García-Blesa Antonio, Yélamos José, Muñoz-Suano Alba, Domínguez-Villar Margarita, Valdor Rut, Alonso Antonio, García-Cózar Francisco, Aparicio Pedro, Malissen Bernard, Aguado Enrique
Abstract excerpt
The adaptor protein LAT has a prominent role in the transduction of intracellular signals elicited by the TCR/CD3 complex. Upon TCR engagement, LAT becomes tyrosine-phosphorylated and thereby, recruits to the membrane several proteins implicated in the activation of downstream signaling pathways. However, little is known about the role of other conserved motifs present in the LAT sequence. Here, we report that...
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