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Article

Evidence that a RecQ helicase slows senescence by resolving recombining telomeres.

PLoS biology - 1 Jun 2007

Lee Julia Y, Kozak Marina, Martin Joel D, Pennock Erin, Johnson F Brad

Abstract excerpt

RecQ helicases, including Saccharomyces cerevisiae Sgs1p and the human Werner syndrome protein, are important for telomere maintenance in cells lacking telomerase activity. How maintenance is accomplished is only partly understood, although there is evidence that RecQ helicases function in telome...

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Share to Aging
Share to Electrophoresis, Gel, Two-Dimensional
Share to Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sequence Analysis, DNA

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Identifiers

PMID: 17550308
DOI: 10.1371/journal.pbio.0050160
PMCID: PMC1885831

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RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17550308-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that a RecQ helicase slows senescence by resolving recombining telomeres.PMID 17550308Read ↗

Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.Semantic proximity Read ↗

Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination.Semantic proximity Read ↗

SGS1 is required for telomere elongation in the absence of telomerase.Semantic proximity Read ↗

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicaseSemantic proximity Read ↗

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Semantic proximity Read ↗

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.Semantic proximity Read ↗

Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity.Semantic proximity Read ↗

Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases.Semantic proximity Read ↗

Defective resection at DNA double-strand breaks leads to de novo telomere formation and enhances gene targeting.Semantic proximity Read ↗

Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescenceSemantic proximity Read ↗

Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution.Semantic proximity Read ↗

Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast.Semantic proximity Read ↗

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