A mutation in <i>Rab27a</i> causes the vesicle transport defects observed in <i>ashen</i> mice

Abstract excerpt

The dilute (d), leaden (ln), and ashen (ash) mutations provide a unique model system for studying vesicle transport in mammals. All three mutations produce a lightened coat color because of defects in pigment granule transport. In addition, all three mutations are suppressed by the semidominant dilute-suppressor (dsu), providing genetic evidence that these mutations function in the same or overlapping transport...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cellular transport and secretion
• Share to Erythrocyte Function and Pathophysiology
• Share to Lysosomal Storage Disorders Research