Analysis of the mechanism of action of non-deletion hereditary persistence of fetal hemoglobin mutants in transgenic mice.

doi:10.1093/emboj/20.1.157

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Article

Analysis of the mechanism of action of non-deletion hereditary persistence of fetal hemoglobin mutants in transgenic mice.

The EMBO journal - 15 Jan 2001

Li Q, Duan Z J, Stamatoyannopoulos G

Abstract excerpt

Transgenic mice carrying an (A)gamma gene construct containing a -382 5' truncation of the (A)gamma gene promoter have a phenotype of hereditary persistence of fetal hemoglobin (HPFH) but, when the CACCC box of the -382(A)gamma promoter is deleted, there is no gamma gene expression in the adult mice. We used this system to investigate the mechanism whereby human HPFH mutations result in gamma gene expression in...

Topics

Animals
Base Sequence
Embryo, Mammalian
Erythropoiesis
Fetal Hemoglobin
Globins
Hemoglobinopathies
Humans
Mice
Mice, Transgenic
Models, Animal
Phenotype
Point Mutation
Promoter Regions, Genetic
Sequence Deletion

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Identifiers

PMID: 11226166
DOI: 10.1093/emboj/20.1.157
PMCID: PMC140187

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