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Article

The role of the -50 region of the human gamma-globin gene in switching.

The EMBO journal - 17 Sept 2001

Ristaldi M S, Drabek D, Gribnau J, Poddie D, Yannoutsous N, Cao A, Grosveld F, Imam A M

Abstract excerpt

During the switch from human gamma- (fetal) to beta- (adult) globin gene expression, the gamma and beta genes are expressed competitively by an alternating transcription mechanism. The -50 region of the gamma gene promoter has been proposed to be responsible for the early competitive advantage of the gamma genes and to act as a stage selector element (SSE) in hemoglobin switching. We analyzed the effect of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11566887
DOI: 10.1093/emboj/20.18.5242
PMCID: PMC125618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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