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Article

Molecular Basis of Hereditary Persistence of Fetal Hemoglobin

1 Jun 1998

Abstract excerpt

Increased levels of fetal hemoglobin (HbF) can ameliorate the clinical course of inherited disorders of beta-globin gene expression, such as beta thalassemia and sickle cell anemia. In a group of disorders called hereditary persistence of fetal hemoglobin (HPFH), expression of the gamma-globin gene of HbF persists at high levels in adult erythroid cells. Molecular studies of the HPFH syndromes have identified...

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PMID: 9668525
DOI: 10.1111/j.1749-6632.1998.tb10460.x

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Basis of Hereditary Persistence of Fetal HemoglobinPMID 9668525Read ↗

G gamma A gamma (beta+) hereditary persistence of fetal hemoglobin: the G gamma -158 C-->T mutation in cis to the -175 T-->C mutation of the A gamma-globin gene results in increased G gamma-globin synthesis.Semantic proximity Read ↗

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Two novel mutations (HBG1: c.-250C > T and HBG2: c.-250C > T) associated with hereditary persistence of fetal hemoglobin.Semantic proximity Read ↗

Identical mutations in the paralogous human γ-globin genes leading to hemoglobin variants and nondeletional hereditary persistence of fetal hemoglobin.Semantic proximity Read ↗

A role for the distal CCAAT box of the gamma-globin gene in Hb switching.Semantic proximity Read ↗

Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expressionSemantic proximity Read ↗

A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin.Semantic proximity Read ↗

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin.Semantic proximity Read ↗

Interpreting elevated fetal hemoglobin in pathology and health at the basic laboratory level: new and known γ- gene mutations associated with hereditary persistence of fetal hemoglobin.Semantic proximity Read ↗

Regulation of human fetal hemoglobin: new players, new complexitiesSemantic proximity Read ↗

The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter.Semantic proximity Read ↗

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