Article
G gamma A gamma (beta+) hereditary persistence of fetal hemoglobin: the G gamma -158 C-->T mutation in cis to the -175 T-->C mutation of the A gamma-globin gene results in increased G gamma-globin synthesis.
American journal of hematology - 1 Feb 1993
Coleman M B, Adams J G, Steinberg M H, Plonczynski M W, Harrell A H, Castro O, Winter W P
Abstract excerpt
Hereditary persistence of fetal hemoglobin (HPFH) can be generally classified into deletional and nondeletional forms. The family described in the present study has characteristics of both types of HPFH. The proband is a healthy 30-year-old black woman. Analysis of her hemoglobin revealed 40.4% H...
Topics
- Adult
- Base Sequence
- Chromosome Mapping
- Female
- Fetal Hemoglobin
- Genes
- Globins
- Hemoglobinopathies
- Humans
- Molecular Probes
- Molecular Sequence Data