Article
The Agamma-195 (C-->G) mutation in hereditary persistence of fetal hemoglobin is not associated with activation of a reporter gene in vitro.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Apr 2001
Schreiber R, Gonçalves M S, Junqueira M L, Saad S T, Krieger J E, Costa F F
Abstract excerpt
Hereditary persistence of fetal hemoglobin is an uncommon, benign disorder in which the expression of gamma-globin genes persists into adult life. Several point mutations have been associated with the increased gamma-globin gene promoter activity. We evaluated the -195 (C-->G) mutation by a functional in vitro assay based on the luciferase reporter gene system. The results indicated that the increased promoter...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.