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Article

Molecular analysis of the human fetal-to-adult globin switching.

The Southeast Asian journal of tropical medicine and public health - 1 Jan 1995

Katsube T, Fucharoen S, Tojo H, Fukumaki Y

Abstract excerpt

Hereditary persistence of fetal hemoglobin (HPFH) is a condition characterized by continued expression of the gamma-globin gene in adult life. Analysis of a Japanese HPFH family had revealed that the C-T transition at position -114 within the distal CCAAT box of the gamma-globin gene associated with the HPFH allele. In the vicinity of the distal CCAAT box, other two mutations (-117 C-T, 13 bp del) had been...

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PMID: 8629109

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular analysis of the human fetal-to-adult globin switching.PMID 8629109Read ↗

A role for the distal CCAAT box of the gamma-globin gene in Hb switching.Semantic proximity Read ↗

Molecular Basis of Hereditary Persistence of Fetal HemoglobinSemantic proximity Read ↗

A novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression.Semantic proximity Read ↗

Analysis of the mechanism of action of non-deletion hereditary persistence of fetal hemoglobin mutants in transgenic mice.Semantic proximity Read ↗

T to C substitution at -175 or -173 of the gamma-globin promoter affects GATA-1 and Oct-1 binding in vitro differently but can independently reproduce the hereditary persistence of fetal hemoglobin phenotype in transgenic mice.Semantic proximity Read ↗

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin.Semantic proximity Read ↗

The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter.Semantic proximity Read ↗

G gamma A gamma (beta+) hereditary persistence of fetal hemoglobin: the G gamma -158 C-->T mutation in cis to the -175 T-->C mutation of the A gamma-globin gene results in increased G gamma-globin synthesis.Semantic proximity Read ↗

Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobinSemantic proximity Read ↗

The T----C substitution at -198 of the A gamma-globin gene associated with the British form of HPFH generates overlapping recognition sites for two DNA-binding proteins.Semantic proximity Read ↗

The -158 (C-->T) promoter mutation is responsible for the increased transcription of the 3' gamma gene in the Atlanta type of hereditary persistence of fetal hemoglobin.Semantic proximity Read ↗

Functional analysis of a novel KLF1 gene promoter variation associated with hereditary persistence of fetal hemoglobin.Semantic proximity Read ↗

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