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Article

Specificity of Cdk activation in vivo by the two Caks Mcs6 and Csk1 in fission yeast.

The EMBO journal - 15 Jan 2001

Hermand D, Westerling T, Pihlak A, Thuret J Y, Vallenius T, Tiainen M, Vandenhaute J, Cottarel G, Mann C, Mäkelä T P

Abstract excerpt

Activating phosphorylation of cyclin-dependent kinases (Cdks) is mediated by at least two structurally distinct types of Cdk-activating kinases (Caks): the trimeric Cdk7-cyclin H-Mat1 complex in metazoans and the single-subunit Cak1 in budding yeast. Fission yeast has both Cak types: Mcs6 is a Cdk7 ortholog and Csk1 a single-subunit kinase. Both phosphorylate Cdks in vitro and rescue a thermosensitive budding...

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Identifiers

PMID: 11226158
DOI: 10.1093/emboj/20.1.82
PMCID: PMC140202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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