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Article

Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast.

Molecular biology of the cell - 1 Jun 2005

Lee Karen M, Miklos Ida, Du Hongyan, Watt Stephen, Szilagyi Zsolt, Saiz Julia E, Madabhushi Ram, Penkett Christopher J, Sipiczki Matthias, Bähler Jürg, Fisher Robert P

Abstract excerpt

The fission yeast Mcs6-Mcs2-Pmh1 complex, homologous to metazoan Cdk7-cyclin H-Mat1, has dual functions in cell division and transcription: as a partially redundant cyclin-dependent kinase (CDK)-activating kinase (CAK) that phosphorylates the major cell cycle CDK, Cdc2, on Thr-167; and as the RNA polymerase (Pol) II carboxyl-terminal domain (CTD) kinase associated with transcription factor (TF) IIH. We analyzed...

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Identifiers

PMID: 15829570
DOI: 10.1091/mbc.e04-11-0982
PMCID: PMC1142420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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