Article
Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1).
Cell stress & chaperones - 1 Sept 2014
Millson Stefan, van Oosten-Hawle Patricija, Alkuriji Mohammed A, Truman Andrew, Siderius Marco, Piper Peter W
Abstract excerpt
In most eukaryotes, Cdc37 is an essential chaperone, transiently associating with newly synthesised protein kinases in order to promote their stabilisation and activation. To determine whether the yeast Cdc37 participates in any stable protein interactions in vivo, genomic two-hybrid screens were conducted using baits that are functional as they preserve the integrity of the conserved N-terminal region of Cdc37,...
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