Article
Correlation between cyclical epithelial barrier dysfunction and bacterial translocation in the relapses of intestinal inflammation
1 Sept 2006
Abstract excerpt
BACKGROUND: Although several factors have been implicated in the pathogenesis of inflammatory bowel disease (IBD), the mechanisms underlying the recurrent relapses have not yet been clarified. We hypothesized that epithelial barrier dysfunction, associated with intestinal motor disturbances, could play a key role in exacerbation of inflammatory illness due to an increased uptake of luminal antigen and bacterial...
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