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Article

Autosomal primary immunodeficiencies affecting human bone marrow B-cell differentiation.

Immunological reviews - 1 Dec 2000

Schiff C, Lemmers B, Deville A, Fougereau M, Meffre E

Abstract excerpt

Since the initial report of X-linked agammaglobulinemia by Bruton, numerous autosomal primary immune deficiencies affecting early B-cell differentiation have been described in humans. The identification of these autosomal mutations has been facilitated by phenotype comparison with knockout mice. In mice, defects in B-cell development have been observed after disruption of genes encoding transcription factors, the...

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Identifiers

PMID: 11213811
DOI: 10.1034/j.1600-065x.2000.17804.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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